建立系列呼吸疾病模型

建立慢阻肺、肺纤维化、环境因素致呼吸疾病等动物模型，为揭示呼吸疾病病理生理与中药作用提供工具。

（1）Li Ya, Li SuYun, Li JianSheng, Deng Li, TianYanGe, Jiang SuLi, Wang Ying, Wang YuanYuan. A rat model for stable chronic obstructive pulmonary disease induced by cigarette smoke inhalation and repetitive bacterial infection. Biol Pharm Bull. 2012, 35(10):1752-1760.

（2）Lu Xiaofan,Li Ya,Li Jiansheng,Wang Haifeng,Wu Zhaohuan,Li Hangjie,Wang Yang. Sequential Treatments with Tongsai and Bufei Yishen Granules Reduce Inflammation and Improve Pulmonary Function in Acute Exacerbation-Risk Window of Chronic Obstructive Pulmonary Disease in Rats. Evid Based Complement Alternat Med. 2016, 2016:1359105.

（3）Li Jiansheng,Li Ya,Lu Xiaofan,Wang Haifeng,Wang Yang,Li Hangjie,Wu Zhaohuan. Dynamic Characteristics of Sequential Acute Exacerbations and Risk Windows in AECOPD Rats Induced by Cigarette-Smoke and Exposure to Klebsiella pneumoniae. Biol Pharm Bull. 2018, 41(10):1543-1553.

（4）Wang Jing,Li Ya,Zhao Peng,Tian Yange,Liu Xuefang,He Huihui,Jia Rui,Oliver Brian G,Li Jiansheng.Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD. Mediators Inflamm. 2020, 2020:4260204.