生物力学平台 |
从生物力学、生物材料学、细胞分子生物学等多学科交叉角度研究呼吸系统疾病的病理机制及药物筛选。可开展力学加载及测试、材料制备及表征、核酸及蛋白分离纯化等实验 (1)Liu Han, Li Moxiao, Huang Gouyou, Li Jiansheng, Xu Feng. Bioinspired Microstructure Platform for Modular Cell-Laden Microgel Fabrication. Macromolecular Bioscience, 2021, 21(9): 2100110. (2)Liu Han, Wu Mian, Jia Yuanbo, Niu Lele, Huang Guoyou, Xu Feng. The Control of Fibroblast Shape in Sequentially Formed 3D Hybrid Hydrogels Regulates Cell Responses to Microenvironmental Cues. NPG Asia Materials, 2020,12:45. (3)Liu Han, Zhou Lihong, Jiao Jiaojiao, Liu Shaobao, Zhang Zhanming, Lu Tian Jian, Xu Feng. Gradient Mechanical Properties Facilitate Arabidopsis Trichome as Mechanosensor. ACS Applied Materials & Interfaces, 2016, 8(15): 9755-9761. (1)国家自然科学基金青年项目,11902245,力学调控的心肌纤维化组织芯片仿生构建及纤维化逆转研究,刘含,2020.01-2022.12,25万元。 (2)中国博士后科学基金面上项目二等资助,2021M690938,基于肺纤维化微组织芯片构建的金水缓纤方干预肺纤维化机制,刘含,2021.06-2023.06,8万元。 (3)河南中医药大学仲景青年学者A类启动基金,刘含,2021.01-2025.12, 80万元。 (1)基于仿生重构自然界表皮毛抓手,开发高通量制备微凝胶新技术,构建不同程度纤维化组织芯片 (2)细胞形状及体积可影响成纤维细胞感知基质硬度及生物化学信号,调控其表型转化 |