代谢组学、脂质组学和蛋白组学方法开发和应用，呼吸疾病生物标志物的筛选、病理机制及中药作用机制研究。

（1） Liu Xinguang, Zhang Hailong, Si Yimei, Du Yan, Wu Jinyan, Li Jiansheng. High-coverage lipidomics analysis reveals biomarkers for diagnosis of acute exacerbation of chronic obstructive pulmonary disease. J Chromatogr B. 2022, 1201-1202: 123278.

（2）Liu Xinguang, Li Jiansheng, Feng Suxiang, Liu Xuefang, Zhao Peng, Zhao Di, Du Yan, Zhang Haojie. A high-resolution MS/MS based strategy to improve xenobiotic metabolites analysis by metabolic pathway extension searching combined with parallel reaction monitoring: Flavonoid metabolism in wound site as a case. J Chromatogr B. 2021, 1162: 122470.

（3）Li Jiansheng, Zhao Peng, Yang Liping, Li Ya, Tian Yange, Li Suyun. System biology analysis of long-term effect and mechanism of Bufei Yishen on COPD revealed by system pharmacology and 3-omics profiling. Sci Rep. 2016, 6: 25492.

国家自然科学基金面上项目，81973781，方证对应治疗AECOPD痰热雍肺证患者的生物效应机制与肠道菌群研究，张海龙，2020.01-2023.12，52.00万元。

（1）基于代谢组学对急性加重期慢阻肺痰湿证和痰热证生物标志物筛选

（2）拟靶向脂质组学方法高覆盖研究呼吸疾病代谢扰动与生物标记筛选

（3）多组学整合研究补肺健脾方治疗慢阻肺作用机制