动物肺功能检测、烟雾暴露、运动、PM2.5染毒，开展动物模型制备及评估、中医药及康复疗效评价和机制探讨。

（1）Jin Fanli, Zhang Lanxi, Chen Kai, Miao Yufang, Liu Yang, Tian Yange, Li Jiansheng. Effective-Component Compatibility of Bufei Yishen Formula III Combined with Electroacupuncture Suppresses Inflammatory Response in Rats with Chronic Obstructive Pulmonary Disease via Regulating SIRT1/NF-κB Signaling. Biomed Res Int. 2022,2022:3360771.

（2）Zhang Lanxi,Tian Yange, Zhao Peng, Feng Suxiang, Han Xiaoxiao, Li Jiansheng. Network pharmacology analysis uncovers the effect on apoptotic pathway by Bu-Fei formula for COPD treatment. J Ethnopharmacol. 2022,289:115022.

（3）Zhang Lanxi, Tian Yange, Zhao Peng, Jin Fanli, Miao Yufang, Liu Yang, Li Jiansheng. Electroacupuncture attenuates pulmonary vascular remodeling in a rat model of chronic obstructive pulmonary disease via the VEGF/PI3K/Akt pathway. Acupunct Med. 2022,9645284221078873.

（4）苗玉芳,张蓝熙,金凡力,闫鑫华,田燕歌,李建生.补肺益肾组分方联合针刺对慢性阻塞性肺疾病大鼠肺小血管的影响[J]. 中国中西医结合杂志, 2021, 41(08): 973-980.

国家自然科学基金面上项目，82074406，基于PKM2调控线粒体氧化应激的补肺益肾组分方改善COPD肺气血屏障损伤机制，田燕歌，2021.01-2022.12，55万元。

（1）制备香烟联合细菌/病毒的慢阻肺小鼠模型

（2）运动康复联合补肺益肾方可改善慢阻肺大鼠骨骼肌功能障碍

（3）针刺联合补肺益肾方可改善慢阻肺大鼠炎症反应、氧化应激和肺血管重构 

（4）PM2.5加重肺纤维化和慢阻肺大鼠的肺功能下降